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Shiga toxin 2a and EnteroaggregativeEscherichia coli– a deadly combination

3 Jun 2015

Abstract excerpt

In 2011, a Shiga toxin (Stx) type 2a-producing enteroaggregative E. coli (EAEC) strain of serotype O104:H4 caused a large lethal outbreak in Northern Europe. Until recently, the pathogenic mechanisms explaining the high virulence of the strain have remained unclear. Our laboratories have shown that EAEC genes encoded on the pAA virulence plasmid, particularly the AggR-regulated AAF/I fimbriae, enhance...

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PMID: 26039753
DOI: 10.1080/19490976.2015.1054591

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