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Article

Long-term survival and blast transformation in molecularly annotated essential thrombocythemia, polycythemia vera, and myelofibrosis.

Blood - 16 Oct 2014

Tefferi Ayalew, Guglielmelli Paola, Larson Dirk R, Finke Christy, Wassie Emnet A, Pieri Lisa, Gangat Naseema, Fjerza Rajmonda, Belachew Alem A, Lasho Terra L, Ketterling Rhett P, Hanson Curtis A, Rambaldi Alessandro, Finazzi Guido, Thiele Juergen, Barbui Tiziano, Pardanani Animesh, Vannucchi Alessandro M

Abstract excerpt

Janus kinase 2 (JAK2) mutations define polycythemia vera (PV). Calreticulin (CALR) and myeloproliferative leukemia virus oncogene (MPL) mutations are specific to JAK2-unmutated essential thrombocythemia (ET) and primary myelofibrosis (PMF). We examined the effect of these mutations on long-term disease outcome. One thousand five hundred eighty-one patients from the Mayo Clinic (n = 826) and Italy (n = 755) were...

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Identifiers

PMID: 25037629
DOI: 10.1182/blood-2014-05-579136
PMCID: PMC4199952

Genes

CALR
JAK2
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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