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Article

Decoding the EGFR mutation-induced drug resistance in lung cancer treatment by local surface geometric properties.

Computers in biology and medicine - 1 Aug 2015

Ma Lichun, Wang Debby D, Huang Yiqing, Wong Maria P, Lee Victor H F, Yan Hong

Abstract excerpt

Epidermal growth factor receptor (EGFR) mutation-induced drug resistance leads to a limited efficacy of tyrosine kinase inhibitors during lung cancer treatments. In this study, we explore the correlations between the local surface geometric properties of EGFR mutants and the progression-free survival (PFS). The geometric properties include local surface changes (four types) of the EGFR mutants compared with the...

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Share to Carcinoma, Non-Small-Cell Lung
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ErbB Receptors

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Share to Protein Structure, Tertiary

Source

Identifiers

PMID: 25035232
DOI: 10.1016/j.compbiomed.2014.06.016

Genes

EGFR

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