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Article

Genetic and molecular predictors of high vancomycin MIC in Staphylococcus aureus bacteremia isolates.

Journal of clinical microbiology - 1 Sept 2014

Holmes Natasha E, Turnidge John D, Munckhof Wendy J, Robinson J Owen, Korman Tony M, O'Sullivan Matthew V N, Anderson Tara L, Roberts Sally A, Warren Sanchia J C, Coombs Geoffrey W, Tan Hui-Leen, Gao Wei, Johnson Paul D R, Howden Benjamin P

Abstract excerpt

An elevated vancomycin MIC is associated with poor outcomes in Staphylococcus aureus bacteremia (SAB) and is reported in patients with methicillin-susceptible S. aureus (MSSA) bacteremia in the absence of vancomycin treatment. Here, using DNA microarray and phenotype analysis, we investigated the genetic predictors and accessory gene regulator (agr) function and their relationship with elevated vancomycin MIC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25031442
DOI: 10.1128/JCM.01320-14
PMCID: PMC4313166

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