Article
Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12.
Neurology - 19 Aug 2014
Kilarski Laura L, Achterberg Sefanja, Devan William J, Traylor Matthew, Malik Rainer, Lindgren Arne, Pare Guillame, Sharma Pankaj, Slowik Agniesczka, Thijs Vincent, Walters Matthew, Worrall Bradford B, Sale Michele M, Algra Ale, Kappelle L Jaap, Wijmenga Cisca, Norrving Bo, Sandling Johanna K, Rönnblom Lars, Goris An, Franke Andre, Sudlow Cathie, Rothwell Peter M, Levi Christopher, Holliday Elizabeth G, Fornage Myriam, Psaty Bruce, Gretarsdottir Solveig, Thorsteinsdottir Unnar, Seshadri Sudha, Mitchell Braxton D, Kittner Steven, Clarke Robert, Hopewell Jemma C, Bis Joshua C, Boncoraglio Giorgio B, Meschia James, Ikram M Arfan, Hansen Bjorn M, Montaner Joan, Thorleifsson Gudmar, Stefanson Kari, Rosand Jonathan, de Bakker Paul I W, Farrall Martin, Dichgans Martin, Markus Hugh S, Bevan Steve
Abstract excerpt
OBJECTIVES: To perform a genome-wide association study (GWAS) using the Immunochip array in 3,420 cases of ischemic stroke and 6,821 controls, followed by a meta-analysis with data from more than 14,000 additional ischemic stroke cases. METHODS: Using the Immunochip, we genotyped 3,420 ischemic stroke cases and 6,821 controls. After imputation we meta-analyzed the results with imputed GWAS data from 3,548 cases...
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