Article
Whole-exome imputation of sequence variants identified two novel alleles associated with adult body height in African Americans.
Human molecular genetics - 15 Dec 2014
Du Mengmeng, Auer Paul L, Jiao Shuo, Haessler Jeffrey, Altshuler David, Boerwinkle Eric, Carlson Christopher S, Carty Cara L, Chen Yii-Der Ida, Curtis Keith, Franceschini Nora, Hsu Li, Jackson Rebecca, Lange Leslie A, Lettre Guillaume, Monda Keri L, Nickerson Deborah A, Reiner Alex P, Rich Stephen S, Rosse Stephanie A, Rotter Jerome I, Willer Cristen J, Wilson James G, North Kari, Kooperberg Charles, Heard-Costa Nancy, Peters Ulrike
Abstract excerpt
Adult body height is a quantitative trait for which genome-wide association studies (GWAS) have identified numerous loci, primarily in European populations. These loci, comprising common variants, explain <10% of the phenotypic variance in height. We searched for novel associations between height and common (minor allele frequency, MAF ≥5%) or infrequent (0.5% < MAF < 5%) variants across the exome in African...
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