Article

Histological Evolution and Signet-ring Cell Transformation in Urachal Adenocarcinoma: A Comprehensive Review of Pathogenesis, Molecular Profiles, and Therapeutic Strategies and Case Report

2026-02-17

Abstract excerpt

<title>Abstract</title> <p>Urachal carcinoma (UrC) is an exceptionally rare and aggressive malignancy arising from the vestigial remnants of the urachus, accounting for less than 1% of all bladder cancers. While mucinous adenocarcinoma is the most frequent subtype, the transformation into signet-ring cell carcinoma (SRCC) represents a critical turning point in the disease's natural history, characterized by extre...

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Literature Corpus work: 11d7ba99-d479-589b-9e59-d9ca05d6fdb8
DOI: 10.21203/rs.3.rs-8855008/v1

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