Article
Helicobacter pylori genome evolution during human infection.
Proceedings of the National Academy of Sciences of the United States of America - 22 Mar 2011
Kennemann Lynn, Didelot Xavier, Aebischer Toni, Kuhn Stefanie, Drescher Bernd, Droege Marcus, Reinhardt Richard, Correa Pelayo, Meyer Thomas F, Josenhans Christine, Falush Daniel, Suerbaum Sebastian
Abstract excerpt
High genetic diversity is a hallmark of the gastric pathogen Helicobacter pylori. We used 454 sequencing technology to perform whole-genome comparisons for five sets of H. pylori strains that had been sequentially cultured from four chronically infected Colombians (isolation intervals=3-16 y) and one human volunteer experimentally infected with H. pylori as part of a vaccine trial. The four sets of genomes from...
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