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Within-host diversity and phased variant analysis reveal structures and recombination of Helicobacter pylori subpopulations in stomach.

GigaScience - 21 Jan 2026

Zhang Xiaomin, Liu Hongjie, Xu Siyue, Zhang Shuang, Yang Tingting, Lei Zhongyi, Xu Weili, Bo Xiaochen, Yang Chenghai, Ni Ming

Abstract excerpt

BACKGROUND: Helicobacter pylori (H. pylori) has a highly plastic genome and can generate substantial within-host diversity during chronic gastric colonization. However, the delineation of its within-host subpopulations, particularly regarding the emergence and spread of antibiotic resistance-conferring mutations, remains poorly understood. RESULTS: In this study, we enrolled 25 chronic gastritis patients from...

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Anti-Bacterial Agents
Drug Resistance, Bacterial
Gastritis
Genome, Bacterial
Helicobacter Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Helicobacter pylori

Recombination, Genetic

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Identifiers

PMID: 41990109
DOI: 10.1093/gigascience/giag046
PMCID: PMC13188224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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