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Article

Induction of cancer stem cell properties in colon cancer cells by defined factors.

PloS one - 1 Jan 2014

Oshima Nobu, Yamada Yasuhiro, Nagayama Satoshi, Kawada Kenji, Hasegawa Suguru, Okabe Hiroshi, Sakai Yoshiharu, Aoi Takashi

Abstract excerpt

Cancer stem cells (CSCs) are considered to be responsible for the dismal prognosis of cancer patients. However, little is known about the molecular mechanisms underlying the acquisition and maintenance of CSC properties in cancer cells because of their rarity in clinical samples. We herein induced CSC properties in cancer cells using defined factors. We retrovirally introduced a set of defined factors (OCT3/4,...

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Identifiers

PMID: 25006808
DOI: 10.1371/journal.pone.0101735
PMCID: PMC4090165

Genes

KLF4
SOX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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