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A Potent HDAC Inhibitor, 1-Alaninechlamydocin, from a <i>Tolypocladium</i> sp. Induces G2/M Cell Cycle Arrest and Apoptosis in MIA PaCa-2 Cells

7 Jul 2014

Abstract excerpt

The cyclic tetrapeptide 1-alaninechlamydocin was purified from a Great Lakes-derived fungal isolate identified as a Tolypocladium sp. Although the planar structure was previously described, a detailed analysis of its spectroscopic data and biological activity are reported here for the first time. Its absolute configuration was determined using a combination of spectroscopic ((1)H-(1)H ROESY, ECD, and X-ray...

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Share to Cholinesterase and Neurodegenerative Diseases
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PMID: 24999749
DOI: 10.1021/np500387h

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