Detection of three closely located single nucleotide polymorphisms in the EAAT2 promoter: comparison of single-strand conformational polymorphism (SSCP), pyrosequencing and Sanger sequencing.

doi:10.1186/1471-2156-15-80

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Article

Detection of three closely located single nucleotide polymorphisms in the EAAT2 promoter: comparison of single-strand conformational polymorphism (SSCP), pyrosequencing and Sanger sequencing.

BMC genetics - 5 Jul 2014

Rajatileka Shavanthi, Luyt Karen, Williams Maggie, Harding David, Odd David, Molnár Elek, Váradi Anikó

Abstract excerpt

BACKGROUND: Single-strand conformational polymorphism (SSCP) is still a frequently used genotyping method across different fields for the detection of single nucleotide polymorphisms (SNPs) due to its simplicity, requirement for basic equipment accessible in most laboratories and low cost. This technique was previously used to detect rs4354668:A > C (g.-181A > C) SNP in the promoter of astroglial glutamate...

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PMID: 24996834
DOI: 10.1186/1471-2156-15-80
PMCID: PMC4112986

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