Article
Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia.
Neurology - 5 Aug 2014
Irwin David J, McMillan Corey T, Suh EunRan, Powers John, Rascovsky Katya, Wood Elisabeth M, Toledo Jon B, Arnold Steven E, Lee Virginia M-Y, Van Deerlin Vivianna M, Trojanowski John Q, Grossman Murray
Abstract excerpt
OBJECTIVE: To determine the prognostic utility of tauopathy-associated single nucleotide polymorphisms (SNPs) in sporadic behavioral-variant frontotemporal dementia (bvFTD). METHODS: Eighty-one patients with sporadic bvFTD were genotyped for tauopathy-associated SNPs at rs8070723 (microtubule-associated protein tau [MAPT]) and rs1768208 (myelin-associated oligodendrocyte basic protein [MOBP]). We performed a...
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