Article
Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2014
Lu Yong-Chen, Yao Xin, Crystal Jessica S, Li Yong F, El-Gamil Mona, Gross Colin, Davis Lindy, Dudley Mark E, Yang James C, Samuels Yardena, Rosenberg Steven A, Robbins Paul F
Abstract excerpt
PURPOSE: Cancer immunotherapy with adoptive transfer of tumor-infiltrating lymphocytes (TIL) represents an effective treatment for patients with metastatic melanoma, with the objective regressions in up to 72% of patients in three clinical trials. However, the antigen targets recognized by these effective TILs remain largely unclear. EXPERIMENTAL DESIGN: Melanoma patients 2359 and 2591 both experienced durable...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antigens, Neoplasm
- Autoantigens
- Cell Line
- Disease Progression
- Epitope Mapping
- Epitopes, T-Lymphocyte
- Gene Library