Article
Highly-sensitive liquid crystal biosensor based on DNA dendrimers-mediated optical reorientation.
Biosensors & bioelectronics - 15 Dec 2014
Tan Hui, Li Xia, Liao Shuzhen, Yu Ruqin, Wu Zhaoyang
Abstract excerpt
A novel highly-sensitive liquid crystal (LC) biosensing approach based on target-triggering DNA dendrimers was developed for the detection of p53 mutation gene segment at the LC-aqueous interface. In this study, the mutant-type p53 gene segment was the target to trigger the formation of DNA dendrimers from hairpin DNA probes by hybridization chain reaction, and the latter as a 'signal enhancement element' further...
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