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Article

Metformin-induced metabolic reprogramming of chemoresistant ALDHbright breast cancer cells.

Oncotarget - 30 Jun 2014

Cioce Mario, Valerio MariaCristina, Casadei Luca, Pulito Claudio, Sacconi Andrea, Mori Federica, Biagioni Francesca, Manetti Cesare, Muti Paola, Strano Sabrina, Blandino Giovanni

Abstract excerpt

Metabolic remodeling is a hallmark of cancer progression and may affect tumor chemoresistance. Here we investigated by 1H-NMR/PCA analysis the metabolic profile of chemoresistant breast cancer cell subpopulations (ALDHbright cells) and their response to metformin, a promising anticancer metabolic modulator. The purified ALDHbright cells exhibited a different metabolic profile as compared to their chemosensitive...

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Identifiers

PMID: 24980829
DOI: 10.18632/oncotarget.1864
PMCID: PMC4147311

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MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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