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Article

Estimating causal effects with a non-paranormal method for the design of efficient intervention experiments.

BMC bioinformatics - 30 Jun 2014

Teramoto Reiji, Saito Chiaki, Funahashi Shin-ichi

Abstract excerpt

BACKGROUND: Knockdown or overexpression of genes is widely used to identify genes that play important roles in many aspects of cellular functions and phenotypes. Because next-generation sequencing generates high-throughput data that allow us to detect genes, it is important to identify genes that drive functional and phenotypic changes of cells. However, conventional methods rely heavily on the assumption of...

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PMID: 24980787
DOI: 10.1186/1471-2105-15-228
PMCID: PMC4087001

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