The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer.

doi:10.1371/journal.pone.0100816

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Article

The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer.

PloS one - 1 Jan 2014

d'Adhemar Charles J, Spillane Cathy D, Gallagher Michael F, Bates Mark, Costello Katie M, Barry-O'Crowley Jacqui, Haley Kathryn, Kernan Niamh, Murphy Ciara, Smyth Paul C, O'Byrne Ken, Pennington Stephen, Cooke Aoife A, Ffrench Brendan, Martin Cara M, O'Donnell Dearbhaile, Hennessy Bryan, Stordal Britta, Finn Stephen, McCann Amanda, Gleeson Noreen, D'Arcy Tom, Flood Brian, O'Neill Luke A J, Sheils Orla, O'Toole Sharon, O'Leary John J

Abstract excerpt

The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential mediator of this resistance. This study aims to provide further evidence that MyD88 positive cancer cells are clinically significant, stem-like and reproducibly detectable for the purposes of...

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Share to Neoplasms, Glandular and Epithelial

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Identifiers

PMID: 24977712
DOI: 10.1371/journal.pone.0100816
PMCID: PMC4076208

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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