Article
Glucocerebrosidase enhancers for selected Gaucher disease genotypes by modification of α-1-C-substituted imino-D-xylitols (DIXs) by click chemistry.
ChemMedChem - 1 Aug 2014
Serra-Vinardell Jenny, Díaz Lucía, Casas Josefina, Grinberg Daniel, Vilageliu Lluïsa, Michelakakis Helen, Mavridou Irene, Aerts Johannes M F G, Decroocq Camille, Compain Philippe, Delgado Antonio
Abstract excerpt
A series of hybrid analogues was designed by combination of the iminoxylitol scaffold of parent 1C9-DIX with triazolylalkyl side chains. The resulting compounds were considered potential pharmacological chaperones in Gaucher disease. The DIX analogues reported here were synthesized by CuAAC click chemistry from scaffold 1 (α-1-C-propargyl-1,5-dideoxy-1,5-imino-D-xylitol) and screened as imiglucerase inhibitors. A...
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