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Article

3,4,5-Trihydroxypiperidine Based Multivalent Glucocerebrosidase (GCase) Enhancers.

Chembiochem : a European journal of chemical biology - 3 Jun 2022

Vanni Costanza, Clemente Francesca, Paoli Paolo, Morrone Amelia, Matassini Camilla, Goti Andrea, Cardona Francesca

Abstract excerpt

The synthesis of five new multivalent derivatives of a trihydroxypiperidine iminosugar was accomplished through copper catalyzed alkyne-azide cycloaddition (CuAAC) reaction of an azido ending piperidine and several propargylated scaffolds. The resulting multivalent architectures were assayed as inhibitors of lysosomal GCase, the defective enzyme in Gaucher disease. The multivalent compounds resulted in much more...

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Identifiers

PMID: 35322924
DOI: 10.1002/cbic.202200077
PMCID: PMC9400994

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