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Article

Probing the Inhibitor versus Chaperone Properties of sp²-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease.

Molecules (Basel, Switzerland) - 17 Apr 2018

Mena-Barragán Teresa, García-Moreno M Isabel, Sevšek Alen, Okazaki Tetsuya, Nanba Eiji, Higaki Katsumi, Martin Nathaniel I, Pieters Roland J, Fernández José M García, Mellet Carmen Ortiz

Abstract excerpt

A series of sp²-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern (d-gluco or l-ido), the architecture of the glycone skeleton, and the nature of the nonglycone substituent has been synthesized and assayed for their inhibition properties towards commercial glycosidases. On the basis of their affinity and selectivity towards GH1 β-glucosidases, reducing and...

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Identifiers

PMID: 29673163
DOI: 10.3390/molecules23040927
PMCID: PMC6017062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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