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Article

Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals

27 Jun 2014

Abstract excerpt

SCOPE: Vitamin D₃, its biologically most active metabolite 1α,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃), and the vitamin D receptor (VDR) are important for adipose tissue biology. METHODS AND RESULTS: We extrapolated genomic VDR association loci in adipocytes from 55 conserved genome-wide VDR-binding sites in nonfat tissues. Taking the genes DUSP10, TRAK1, NRIP1, and THBD as examples, we confirmed the predicted VDR...

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PMID: 24975273
DOI: 10.1002/mnfr.201400291

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