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Article

[Selection of heparin-sensitive dengue virus variants in BHK-21 cells].

Investigacion clinica - 1 Jun 2014

Celis Argelia, Moros Zoila, Gerder Marlene, Pagano Francesca, Vizzi Esmeralda, Liprandi Ferdinando

Abstract excerpt

Several studies have shown that adaptation of various viruses to grow in certain cell lines of vertebrates, leads to the selection of virus variants that bind heparan sulfate (HS) with high affinity. In this study we investigated the susceptibility of strains of dengue virus (DENV) to oversulfated heparin an analogue of HS after passages in BHK-21 cells. Field isolates of the four serotypes of DENV with a limited...

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PMID: 24974631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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