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Article

Genetic variants of APOC3 promoter and HLA-B genes in an HIV infected cohort in northern South Africa: a pilot study.

International journal of molecular sciences - 26 Jun 2014

Masebe Tracy, Bessong Pascal Obong, Ndip Roland Ndip, Meyer Debra

Abstract excerpt

Metabolic disorders and hypersensitivities affect tolerability and impact adherence to highly active antiretroviral therapy (HAART). The aim of this study was to determine the prevalence of C-482T/T-455C variants in the Apolipoprotein C3 (APOC3) promoter gene and Human leukocyte antigen (HLA)-B*57:01, known to impact lipid metabolic disorders and hypersensitivity respectively; and to correlate genotypes with...

Topics

Adolescent
Adult
Apolipoproteins C
CD4 Lymphocyte Count
Female
HIV Infections
HLA-B Antigens
Humans
Male
Middle Aged
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

South Africa

Source

Open in PubMed Open full text

Identifiers

PMID: 24972136
DOI: 10.3390/ijms150711403
PMCID: PMC4139789

Genes

APOC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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