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Insulin administration may trigger type 1 diabetes in Japanese type 2 diabetes patients with type 1 diabetes high-risk HLA class II and the insulin gene VNTR genotype.

The Journal of clinical endocrinology and metabolism - 1 Sept 2014

Nishida Wataru, Nagata Masao, Imagawa Akihisa, Hanafusa Toshiaki, Ohashi Jun, Takahashi Kenji, Suehiro Tadashi, Yamada Yuya, Chujo Daisuke, Kawasaki Eiji, Kawamura Ryoichi, Onuma Hiroshi, Osawa Haruhiko, Makino Hideichi

Abstract excerpt

CONTEXT: Insulin administration causes various types of immune responses to insulin. We previously reported three cases of type 1 diabetes mellitus (T1DM) triggered by insulin administration in Japanese type 2 diabetes mellitus patients. OBJECTIVE: The objective of this study was to collect information and characterize insulin-triggered T1DM immunologically and genetically. METHODS: Data for six patients (four...

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PMID: 24971665
DOI: 10.1210/jc.2014-1759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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