Article
Use of proscribed chloroquine is associated with an increased risk of pfcrt T76 mutation in some parts of Ghana.
Malaria journal - 26 Jun 2014
Asare Kwame K, Boampong Johnson N, Afoakwah Richmond, Ameyaw Elvis O, Sehgal Rakesh, Quashie Neils B
Abstract excerpt
BACKGROUND: After years of disuse of chloroquine (CQ) as first-line anti-malarial drug in Ghana, reports from molecular studies conducted in parts of the country indicate varying prevalence of T76 mutation in the pfcrt gene. This situation has several health implications, one being that mutations that confer resistance to CQ have been reported to show substantial cross-resistance to other anti-malarial drugs. It...
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