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Article

Lack of influence of the SMAD7 gene rs2337107 polymorphism on risk of colorectal cancer in an Iranian population.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014

Akbari Zahra, Safari-Alighiarloo Nahid, Haghighi Mahdi Montazer, Vahedi Mohsen, Mirtalebi Hanieh, Azimzadeh Pedram, Milanizadeh Saman, Shemirani Atena Irani, Nazemalhosseini-Mojarad Ehsan, Aghdaei Hamid Asadzadeh, Zali Mohammad Reza

Abstract excerpt

SMAD7 has been identified as a functional candidate gene for colorectal cancer (CRC). SMAD7 protein is a known antagonist of the transforming growth factor beta (TGF-β) signaling pathway which is involved in tumorigenesis. Polymorphisms in SMAD7 may thus alter cancer risk. The aim of this study was to investigate the influence of a SMAD7 gene polymorphism (rs2337107) on risk of CRC and clinicopathological...

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Identifiers

PMID: 24969865
DOI: 10.7314/apjcp.2014.15.11.4437

Genes

SMAD7

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