Article
Epigenetic genes and emotional reactivity to daily life events: a multi-step gene-environment interaction study.
PloS one - 1 Jan 2014
Pishva Ehsan, Drukker Marjan, Viechtbauer Wolfgang, Decoster Jeroen, Collip Dina, van Winkel Ruud, Wichers Marieke, Jacobs Nele, Thiery Evert, Derom Catherine, Geschwind Nicole, van den Hove Daniel, Lataster Tineke, Myin-Germeys Inez, van Os Jim, Rutten Bart P F, Kenis Gunter
Abstract excerpt
Recent human and animal studies suggest that epigenetic mechanisms mediate the impact of environment on development of mental disorders. Therefore, we hypothesized that polymorphisms in epigenetic-regulatory genes impact stress-induced emotional changes. A multi-step, multi-sample gene-environment interaction analysis was conducted to test whether 31 single nucleotide polymorphisms (SNPs) in epigenetic-regulatory...
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