Article
Accurate quantitation of JAK2 V617F allele burden by array-based digital PCR.
International journal of laboratory hematology - 1 Apr 2015
Kinz E, Leiherer A, Lang A H, Drexel H, Muendlein A
Abstract excerpt
INTRODUCTION: The JAK2 V617F mutation is highly prevalent in patients with myeloproliferative neoplasms (MPN). Several studies have shown that allele burden correlates with hematologic characteristics and clinical end-points in patients with MPN. Allele-specific real-time quantitative polymerase chain reaction (RQ-PCR) is probably the most commonly used technique for detection and quantitation of the JAK2 V617F...
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