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Article

Characterization of SEMA3A-encoded semaphorin as a naturally occurring Kv4.3 protein inhibitor and its contribution to Brugada syndrome.

Circulation research - 1 Aug 2014

Boczek Nicole J, Ye Dan, Johnson Eric K, Wang Wei, Crotti Lia, Tester David J, Dagradi Federica, Mizusawa Yuka, Torchio Margherita, Alders Marielle, Giudicessi John R, Wilde Arthur A M, Schwartz Peter J, Nerbonne Jeanne M, Ackerman Michael J

Abstract excerpt

RATIONALE: Semaphorin 3A (SEMA3A)-encoded semaphorin is a chemorepellent that disrupts neural patterning in the nervous and cardiac systems. In addition, SEMA3A has an amino acid motif that is analogous to hanatoxin, an inhibitor of voltage-gated K(+) channels. SEMA3A-knockout mice exhibit an abnormal ECG pattern and are prone to ventricular arrhythmias and sudden cardiac death. OBJECTIVE: Our aim was to...

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Identifiers

PMID: 24963029
DOI: 10.1161/CIRCRESAHA.115.303657
PMCID: PMC4907370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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