Article
Phenotypic and genotypic characterization of azacitidine-sensitive and resistant SKM1 myeloid cell lines.
Oncotarget - 30 Jun 2014
Cluzeau Thomas, Dubois Alix, Jacquel Arnaud, Luciano Frederic, Renneville Aline, Preudhomme Claude, Karsenti Jean Michel, Mounier Nicolas, Rohrlich Pierre, Raynaud Sophie, Mari Bernard, Robert Guillaume, Auberger Patrick
Abstract excerpt
In the present study, we provide a comparative phenotypic and genotypic analysis of azacitidine-sensitive and resistant SKM-1 cell lines. Morphologically, SKM1-R exhibited increase in cell size that accounts for by enhanced ploidy in a majority of cells as shown by cell cycle and karyotype analysis. No specific Single Nucleotide Polymorphism (SNP) alteration was found in SKM1-R cells compared to their SKM1-S...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
