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Article

NADPH oxidase 4 induces cardiac arrhythmic phenotype in zebrafish.

The Journal of biological chemistry - 15 Aug 2014

Zhang Yixuan, Shimizu Hirohito, Siu Kin Lung, Mahajan Aman, Chen Jau-Nian, Cai Hua

Abstract excerpt

Oxidative stress has been implicated in cardiac arrhythmia, although a causal relationship remains undefined. We have recently demonstrated a marked up-regulation of NADPH oxidase isoform 4 (NOX4) in patients with atrial fibrillation, which is accompanied by overproduction of reactive oxygen species (ROS). In this study, we investigated the impact on the cardiac phenotype of NOX4 overexpression in zebrafish....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2

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Source

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Identifiers

PMID: 24962575
DOI: 10.1074/jbc.M114.587196
PMCID: PMC4132817

Genes

NOX4
AIP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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