Article
High-resolution cardiovascular function confirms functional orthology of myocardial contractility pathways in zebrafish.
Physiological genomics - 7 Jul 2010
Shin Jordan T, Pomerantsev Eugene V, Mably John D, MacRae Calum A
Abstract excerpt
Phenotype-driven screens in larval zebrafish have transformed our understanding of the molecular basis of cardiovascular development. Screens to define the genetic determinants of physiological phenotypes have been slow to materialize as a result of the limited number of validated in vivo assays with relevant dynamic range. To enable rigorous assessment of cardiovascular physiology in living zebrafish embryos, we...
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