Article
Genetic abnormalities in Waldenström's macroglobulinemia.
Clinical lymphoma & myeloma - 1 Mar 2009
Adamia Sophia, Pilarski Patrick M, Belch Andrew R, Pilarski Linda M
Abstract excerpt
The genetic factors that lead to WM are mostly unknown but are likely to involve inherited polymorphisms that might be markers of increased risk for developing WM, and somatic mutations that might be acquired during the events leading to oncogenesis and cancer progression. By intensive sequencing of the hyaluronan synthase 1 (HAS1) gene in malignant and normal cells from patients with WM, we have identified both...
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