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Article

Corrector VX-809 stabilizes the first transmembrane domain of CFTR.

Biochemical pharmacology - 1 Sept 2013

Loo Tip W, Bartlett M Claire, Clarke David M

Abstract excerpt

Processing mutations that inhibit folding and trafficking of CFTR are the main cause of cystic fibrosis (CF). A potential CF therapy would be to repair CFTR processing mutants. It has been demonstrated that processing mutants of P-glycoprotein (P-gp), CFTR's sister protein, can be efficiently repaired by a drug-rescue mechanism. Many arginine suppressors that mimic drug-rescue have been identified in the P-gp...

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Source

Identifiers

PMID: 23835419
DOI: 10.1016/j.bcp.2013.06.028

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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