Article
Cannabinoid receptor 2-63 QQ variant is associated with persistently normal aminotransferase serum levels in chronic hepatitis C.
PloS one - 1 Jan 2014
Coppola Nicola, Zampino Rosa, Sagnelli Caterina, Bellini Giulia, Marrone Aldo, Stanzione Maria, Capoluongo Nicolina, Boemio Adriana, Minichini Carmine, Adinolfi Luigi Elio, Maione Sabatino, Del Giudice Emanuele Miraglia, Sagnelli Evangelista, Rossi Francesca
Abstract excerpt
BACKGROUND AND AIM: To evaluate in anti-HCV-positive patients the clinical impact of the rs35761398 variant of the CNR2 gene leading to the substitution of Gln (Q) of codon 63 of the cannabinoid receptor 2 (CB2) with Arg (R). PATIENTS AND METHODS: 253 consecutive anti-HCV-/HCV-RNA-positive patients were enrolled, of whom 53 were HCV carriers with persistently normal ALT (PNALT group) and 200 had a history of...
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