Article
Phenotypic drug screening and target validation for improved personalized therapy reveal the complexity of phenotype-genotype correlations in clear cell renal cell carcinoma.
Urologic oncology - 1 Aug 2014
Schneider Meike, Schüler Julia, Höfflin Rouven, Korzeniewski Nina, Grüllich Carsten, Roth Wilfried, Teber Dogu, Hadaschik Boris, Pahernik Sascha, Hohenfellner Markus, Duensing Stefan
Abstract excerpt
OBJECTIVES: Novel personalized therapeutic approaches are urgently needed for patients with metastatic clear cell renal cell carcinoma (ccRCC). METHODS AND MATERIALS: We combined the development of a primary patient-derived ccRCC cell line with a phenotypic drug screen consisting of 101 approved anticancer compounds. RESULTS: We identified the MNNG HOS transforming gene (MET)-anaplastic lymphoma receptor tyrosine...
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