Article
BDNF Val66Met polymorphism in primary adult-onset dystonia: a case-control study and meta-analysis.
Movement disorders : official journal of the Movement Disorder Society - 1 Jul 2014
Gómez-Garre Pilar, Huertas-Fernández Ismael, Cáceres-Redondo María Teresa, Alonso-Canovas Araceli, Bernal-Bernal Inmaculada, Blanco-Ollero Alberto, Bonilla-Toribio Marta, Burguera Juan Andrés, Carballo Manuel, Carrillo Fátima, Catalán-Alonso María José, Escamilla-Sevilla Francisco, Espinosa-Rosso Raúl, Fernández-Moreno María Carmen, García-Caldentey Juan, García-Moreno José Manuel, García-Ruiz Pedro José, Giacometti-Silveira Sandra, Gutiérrez-García Javier, Jesús Silvia, López-Valdés Eva, Martínez-Castrillo Juan Carlos, Martínez-Torres Irene, Medialdea-Natera María Pilar, Méndez-Lucena Carolina, Mínguez-Castellanos Adolfo, Moya Miguel, Ochoa-Sepulveda Juan José, Ojea Tomás, Rodríguez Nuria, Sillero-Sánchez Miriam, Vargas-González Laura, Mir Pablo
Abstract excerpt
BACKGROUND: A polymorphism in brain-derived neurotrophic factor (BDNF) (Val66Met) has been reported as a risk factor in primary dystonia. However, overall the results have been inconclusive. Our aim was to clarify the association of Val66Met with primary dystonia, and with the most prevalent clinical subtypes, cervical dystonia and blepharospasm. METHODS: We conducted a Spanish multicenter case-control study...
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