Dark matter RNA illuminates the puzzle of genome-wide association studies.

Abstract excerpt

In the past decade, numerous studies have made connections between sequence variants in human genomes and predisposition to complex diseases. However, most of these variants lie outside of the charted regions of the human genome whose function we understand; that is, the sequences that encode proteins. Consequently, the general concept of a mechanism that translates these variants into predisposition to diseases...

Topics

• Animals
• Base Sequence
• Genetic Predisposition to Disease
• Genetic Variation
• Genome, Human
• Genome-Wide Association Study
• Genotype
• Humans
• RNA, Untranslated
• Transcription, Genetic