Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NOTCH1 mutations identify a chronic lymphocytic leukemia patient subset with worse prognosis in the setting of a rituximab-based induction and consolidation treatment.

Annals of hematology - 1 Oct 2014

Bo Michele Dal, Del Principe Maria Ilaria, Pozzo Federico, Ragusa Dario, Bulian Pietro, Rossi Davide, Capelli Giovanni, Rossi Francesca Maria, Niscola Pasquale, Buccisano Francesco, Bomben Riccardo, Zucchetto Antonella, Maurillo Luca, de Fabritiis Paolo, Amadori Sergio, Gaidano Gianluca, Gattei Valter, Del Poeta Giovanni

Abstract excerpt

Induction therapy with fludarabine followed by rituximab and consolidation plus maintenance with rituximab improved response duration (RD) and overall survival (OS) in our patients with chronic lymphocytic leukemia (CLL). The aim of our study was to investigate the clinical impact of NOTCH1 mutat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal, Murine-Derived
Share to Genes, Immunoglobulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm, Residual

Share to Receptor, Notch1

Share to Remission Induction

Share to Rituximab

Share to Vidarabine

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Identifiers

PMID: 24923451
DOI: 10.1007/s00277-014-2117-x

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24923451-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NOTCH1 mutations identify a chronic lymphocytic leukemia patient subset with worse prognosis in the setting of a rituximab-based induction and consolidation treatment.PMID 24923451Read ↗

Clinical Value of NOTCH1 Mutations Detection among Chronic Lymphocytic Leukemia Patients.Semantic proximity Read ↗

NOTCH1, SF3B1, BIRC3 and TP53 mutations in patients with chronic lymphocytic leukemia undergoing first-line treatment: correlation with biological parameters and response to treatment.Semantic proximity Read ↗

Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial.Semantic proximity Read ↗

Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia.Semantic proximity Read ↗

Chemoimmunotherapy with fludarabine and rituximab produces extended overall survival and progression-free survival in chronic lymphocytic leukemia: long-term follow-up of CALGB study 9712.Semantic proximity Read ↗

Chronic lymphocytic leukemia: a clinical review including Korean cohorts.Semantic proximity Read ↗

Cytogenetic prioritization with inclusion of molecular markers predicts outcome in previously untreated patients with chronic lymphocytic leukemia treated with fludarabine or fludarabine plus cyclophosphamide: a long-term follow-up study of the US intergroup phase III trial E2997.Semantic proximity Read ↗

Prognostic impact of NOTCH1, MYD88, and SF3B1 mutations in Polish patients with chronic lymphocytic leukemia.Semantic proximity Read ↗

Landscape of NOTCH1 mutations and co-occurring biomarker alterations in chronic lymphocytic leukemia.Semantic proximity Read ↗

Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): a study on 852 patientsSemantic proximity Read ↗

Modern treatment in chronic lymphocytic leukemia: impact on survival and efficacy in high-risk subgroups.Semantic proximity Read ↗

NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.