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Intrahost population dynamics of chikungunya virus in humans and naturally infected Aedes mosquitoes reveal transmission-driven diversity

22 Dec 2025

Abstract excerpt

RNA viruses exhibit a high mutation rate, contributing to their genetic diversity mainly because their RNA polymerase lacks proofreading ability. Arboviruses, which alternate between vertebrate and invertebrate hosts, are subjected to host-specific selective pressures and population bottlenecks, mainly within mosquito vectors. Although experimental studies have brought insights into their evolutionary dynamics,...

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PMID: 41607870
DOI: 10.1093/ve/veaf102

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