Article
Association between the p27 rs2066827 variant and tumor multiplicity in patients harboring MEN1 germline mutations.
European journal of endocrinology - 1 Sept 2014
Longuini Viviane C, Lourenço Delmar M, Sekiya Tomoko, Meirelles Osorio, Goncalves Tatiana D, Coutinho Flavia L, Francisco Guilherme, Osaki Luciana H, Chammas Roger, Alves Venancio A F, Siqueira Sheila A C, Schlesinger David, Naslavsky Michel S, Zatz Mayana, Duarte Yeda A O, Lebrão Maria Lucia, Gama Patricia, Lee Misu, Molatore Sara, Pereira Maria Adelaide A, Jallad Raquel S, Bronstein Marcello D, Cunha-Neto Malebranche B, Liberman Bernardo, Fragoso Maria Candida B V, Toledo Sergio P A, Pellegata Natalia S, Toledo Rodrigo A
Abstract excerpt
OBJECTIVE: To date, no evidence of robust genotype-phenotype correlation or disease modifiers for multiple endocrine neoplasia type 1 (MEN1) syndrome has been described, leaving the highly variable clinical presentation of patients unaccounted for. DESIGN: As the CDKN1B (p27) gene causes MEN4 syndrome and it is transcriptionally regulated by the product of the MEN1 gene (menin), we sought to analyze whether p27...
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