Association between the p27 rs2066827 variant and tumor multiplicity in patients harboring MEN1 germline mutations.

doi:10.1530/EJE-14-0130

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Article

Association between the p27 rs2066827 variant and tumor multiplicity in patients harboring MEN1 germline mutations.

European journal of endocrinology - 1 Sept 2014

Longuini Viviane C, Lourenço Delmar M, Sekiya Tomoko, Meirelles Osorio, Goncalves Tatiana D, Coutinho Flavia L, Francisco Guilherme, Osaki Luciana H, Chammas Roger, Alves Venancio A F, Siqueira Sheila A C, Schlesinger David, Naslavsky Michel S, Zatz Mayana, Duarte Yeda A O, Lebrão Maria Lucia, Gama Patricia, Lee Misu, Molatore Sara, Pereira Maria Adelaide A, Jallad Raquel S, Bronstein Marcello D, Cunha-Neto Malebranche B, Liberman Bernardo, Fragoso Maria Candida B V, Toledo Sergio P A, Pellegata Natalia S, Toledo Rodrigo A

Abstract excerpt

OBJECTIVE: To date, no evidence of robust genotype-phenotype correlation or disease modifiers for multiple endocrine neoplasia type 1 (MEN1) syndrome has been described, leaving the highly variable clinical presentation of patients unaccounted for. DESIGN: As the CDKN1B (p27) gene causes MEN4 syn...

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Identifiers

PMID: 24920291
DOI: 10.1530/EJE-14-0130

Genes

MEN1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24920291-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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