Article
p27 variant and corticotropinoma susceptibility: a genetic and in vitro study.
Endocrine-related cancer - 1 Jun 2014
Sekiya Tomoko, Bronstein Marcello D, Benfini Katiuscia, Longuini Viviane C, Jallad Raquel S, Machado Marcio C, Goncalves Tatiana D, Osaki Luciana H, Higashi Leonardo, Viana Jose, Kater Claudio, Lee Misu, Molatore Sara, Francisco Guilherme, Chammas Roger, Naslavsky Michel S, Schlesinger David, Gama Patricia, Duarte Yeda A O, Lebrão Maria Lucia, Zatz Mayana, Meirelles Osorio, Liberman Bernardo, Fragoso Maria Candida B V, Toledo Sergio P A, Pellegata Natalia S, Toledo Rodrigo A
Abstract excerpt
Germline mutations in p27(kip1) are associated with increased susceptibility to multiple endocrine neoplasias (MEN) both in rats and humans; however, the potential role of common polymorphisms of this gene in endocrine tumor susceptibility and tumorigenesis remains mostly unrecognized. To assess the risk associated with polymorphism rs2066827 (p27-V109G), we genotyped a large cohort of Brazilian patients with...
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