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Article

Age-related axonal swellings precede other neuropathological hallmarks in a knock-in mouse model of Huntington's disease

9 May 2014

Abstract excerpt

Axon degeneration precedes cell body death in many age-related neurodegenerative disorders, often determining symptom onset and progression. A sensitive method for revealing axon pathology could indicate whether this is the case also in Huntington's disease (HD), a fatal, devastating neurodegenerative disorder causing progressive deterioration of both physical and mental abilities, and which brain region is...

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PMID: 24906892
DOI: 10.1016/j.neurobiolaging.2014.04.024

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