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Searching for large genomic rearrangements of the BRCA1 gene in a Nigerian population.

Breast cancer research and treatment - 1 Nov 2010

Zhang Jing, Fackenthal James D, Huo Dezheng, Zheng Yonglan, Olopade Olufunmilayo I

Abstract excerpt

BRCA1/2 germline mutations predispose to breast and ovarian cancer. Large genomic rearrangements (LGRs) have widened the mutational spectrum of the BRCA1 gene, but the frequencies vary in different populations. In this study, we want to determine the spectrum of LGRs in BRCA1 gene in Nigerian breast cancer patients. The multiplex ligation-dependent probe amplification (MLPA) assay was used to screen BRCA1...

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Identifiers

PMID: 20596889
DOI: 10.1007/s10549-010-1006-9

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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