Article
Integrated pathway-based approach identifies association between genomic regions at CTCF and CACNB2 and schizophrenia.
PLoS genetics - 1 Jun 2014
Juraeva Dilafruz, Haenisch Britta, Zapatka Marc, Frank Josef, Witt Stephanie H, Mühleisen Thomas W, Treutlein Jens, Strohmaier Jana, Meier Sandra, Degenhardt Franziska, Giegling Ina, Ripke Stephan, Leber Markus, Lange Christoph, Schulze Thomas G, Mössner Rainald, Nenadic Igor, Sauer Heinrich, Rujescu Dan, Maier Wolfgang, Børglum Anders, Ophoff Roel, Cichon Sven, Nöthen Markus M, Rietschel Marcella, Mattheisen Manuel, Brors Benedikt
Abstract excerpt
In the present study, an integrated hierarchical approach was applied to: (1) identify pathways associated with susceptibility to schizophrenia; (2) detect genes that may be potentially affected in these pathways since they contain an associated polymorphism; and (3) annotate the functional consequences of such single-nucleotide polymorphisms (SNPs) in the affected genes or their regulatory regions. The Global...
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