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Article

Influence of UGT1A1 6, 27, and 28 polymorphisms on nilotinib-induced hyperbilirubinemia in Japanese patients with chronic myeloid leukemia.

Drug metabolism and pharmacokinetics - 1 Jan 2014

Abumiya Maiko, Takahashi Naoto, Niioka Takenori, Kameoka Yoshihiro, Fujishima Naohito, Tagawa Hiroyuki, Sawada Kenichi, Miura Masatomo

Abstract excerpt

Nilotinib potently inhibits human uridine diphosphate-glucuronosyltransferase (UGT1A1) activity, causing hyperbilirubinemia. We investigated the influence of UGT1A1 polymorphisms and nilotinib plasma trough concentrations (C0) on nilotinib-induced hyperbilirubinemia in 34 Japanese patients with chronic myeloid leukemia (CML). The proportion of patients with hyperbilirubinemia was significantly higher among...

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Identifiers

PMID: 24898899
DOI: 10.2133/dmpk.DMPK-14-RG-031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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