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Article

Contribution of UGT1A1 variations to chemotherapy-induced unconjugated hyperbilirubinemia in pediatric leukemia patients.

Pediatric research - 1 Aug 2016

Nomura Akitaka, Maruo Yoshihiro, Taga Takashi, Takeuchi Yoshihiro

Abstract excerpt

BACKGROUND: Chemotherapy for malignant neoplasms sometimes induces unconjugated hyperbilirubinemia, resulting in the early cessation of treatment. We evaluated the role of variations in the bilirubin uridine-5-diphosphate (UDP)-glucuronosyltransferase gene (UGT1A1) in unconjugated hyperbilirubinemia development during chemotherapy in pediatric patients with leukemia. METHODS: UGT1A1 allelic variations were...

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Identifiers

PMID: 27057738
DOI: 10.1038/pr.2016.75

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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