Genetic association of objective sleep phenotypes with a functional polymorphism in the neuropeptide S receptor gene.

doi:10.1371/journal.pone.0098789

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Article

Genetic association of objective sleep phenotypes with a functional polymorphism in the neuropeptide S receptor gene.

PloS one - 1 Jan 2014

Spada Janek, Sander Christian, Burkhardt Ralph, Häntzsch Madlen, Mergl Roland, Scholz Markus, Hegerl Ulrich, Hensch Tilman

Abstract excerpt

BACKGROUND: The neuropeptide S receptor (NPSR1) and its ligand neuropeptide S (NPS) have received increased attention in the last few years, as both establish a previously unknown system of neuromodulation. Animal research studies have suggested that NPS may be involved in arousal/wakefulness and may also have a crucial role in sleep regulation. The single nucleotide polymorphism (SNP) rs324981 in NPSR1 has begun...

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Identifiers

PMID: 24896296
DOI: 10.1371/journal.pone.0098789
PMCID: PMC4045816

Genes

NPS
NPSR1

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