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Article

MiR-186 targets ROCK1 to suppress the growth and metastasis of NSCLC cells.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Sept 2014

Cui Guanghui, Cui Mingwei, Li Yuhang, Liang Youguang, Li Weihao, Guo Haizhou, Zhao Song

Abstract excerpt

MicroRNAs (miRNAs) act as oncogenes or tumor suppressors in human cancers. Increasing evidence shows that deregulation of miRNAs contributes to the development and progression of human non-small cell lung cancer (NSCLC). Here, we identified miR-186 as a tumor suppressor in NSCLC, which was decreased in NSCLC. Overexpression of miR-186 significantly inhibited proliferation, migration, and invasion of NSCLC cells....

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Source

Identifiers

PMID: 24894676
DOI: 10.1007/s13277-014-2168-6

Genes

ROCK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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